Quality Control and Food Safety

Innovative Analytical Methodologies Control
of Quality and Food Safety

Scientific Publications 2012




- L. Ramos. Critical Overview of Selected Contemporary Sample Preparation Techniques". J. Chromatogr. A 2112: 84-98 (2012).

- S. El-Amrani, J. Sanz-Landaluze, L. Ramos, M. Pena-Abaurrea, J. Guinea, C. Cámara. Bioconcentration of pesticides in larvae Zebrafish eleutheroembryos (Danio rerio)". Sci. Total Environ. 425: 184-190 (2012).

- L. Ruiz-Aceituno, L. Ramos, L., Martinez-Castro, I., Sanz, M.L. Low molecular weight carbohydrates in pine nuts from Pinus Pinea L." J. Agric. Food Chem. 60: 4957-4959 (2012).

- M. Pena-Abaurrea, J. Blasco, L. Ramos.Comprehensive two-dimensional gas-chromatography-time-of-flight mass spectrometry for the determination of high-molecular weight polyaromatic hydrocarbons in sediments" J. Chromatogr. A 1256: 222-231 (2012).

- L. Ruiz-Aceituno, L. Ramos Rivero, M.L. Sanz Murias. “ Inositoles en alimentos: estructura, propiedades y funcionalidad" Alim. Nutri. Salud 19(1): 1-12 (2012).

- Maria Luisa Ruíz del Castillo, Mónica Rodríguez-Valenciano, Fernando de la Peña Moreno y Gracia Patricia Blanch. Evaluation of pesticide residue contents in fruit juice by solid-phase microextraction and multidimensional gas chromatography coupled
with mass spectrometry"
. Talanta 89 (2012) 77-83

- Morales, F.J., Somoza, V., Fogliano, V. Physiological relevance of dietary melanoidins. Amino Acids, (2012), 42 (4), 1097-1109. http://dx.doi.org./10.1007/s00726-010-0774-1

- Pastoriza, S., Rufián-Henares, J.A., Morales, F.J. Reactivity of acrylamide with coffee melanoidins in model systems. LWT - Food Science and Technology. (2012), 45, 198-203. http://dx.doi.org/10.1016/j.lwt.2011.08.004

- Delgado-Andrade, C., Mesías, M., Morales, F.J., Seiquer, I., & Navarro, M.P. Assessment of acrylamide intake of Spanish boys aged 11-14 years consuming a traditional and balanced diet. LWT - Food Science and Technology. (2012), 46 (1), 16-22. http://dx.doi.org/10.1016/j.lwt.2011.11.006, http://www.sciencedirect.com/science/article/pii/S0023643811003616

- Pereira-Caro, G., Mateos, R., Sarria, B., Cert, R., Goya, L., Bravo, L. Hydroxytyrosyl acetate contributes to the protective effects against oxidative stress of virgin olive oil. Food Chem. 131 (2012), 869-878

- J.M. Santiuste, J.E. Quintanilla-López, J.M. Takács, R. Lebrón-Aguilar, Behaviour of the isothermal retention indices of n-alkylbenzenes on stationary phases of different polarity, J. Chromatogr. A, 1222 (2012) 90-97

- F. Sánchez-Patán, C. Cueva, M. Monagas, G.E. Walton, G.R. Gibson, J.E. Quintanilla-López, R. Lebrón-Aguilar, P.J. Martín-Álvarez, M.V.  Moreno-Arribas, B. Bartolomé, In vitro fermentation of a red wine extract by human gut microbiota: changes in microbial groups and formation of phenolic metabolites, J. Agric. Food Chem., 60 (2012) 2136-2147.

- B. Gómara, M. Athanasiadou, J. E. Quintanilla-López, M.J. González, Å. Bergman, Polychlorinated biphenyls and their hydroxylated metabolites in placenta from Madrid mothers, Environ. Sci. Pollut. Res., 19 (2012) 139–147.

- V. Pérez-Fernández, M. Castro-Puyana, M.J. González, M.L. Marina, M.A. García and B. Gómara. "Simultaneous enantioselective separation of polychlorinated biphenyls and their methyl sulfone metabolites by heart-cut MDGC. Determination of enantiomeric fractions in fish oils and cow liver samples". Chirality (2012) 24: 577-583. DOI: 10.1002/chir.22062

- García-Martínez, M.C., Holgado, F., Velasco, J. and Márquez-Ruiz, G. "Effect of classic sterilization on lipid oxidation in model liquid milk-based infant and follow-on formulas. Eur. J. Lipid Sci. Technol. 2012, 114, 1373–1380. DOI: 10.1002/ejlt.201200156.

- S. Cuello, J. Sanz, Y.Madrid, C. Cámara. "Bioaccumulation and transformation of methylmercury and selenite using zebrafish (Danio Rerio) larvae as a model". Talanta, 89, 169-177 (Ene 2012)

- E.López-Tobar, G.P.Blanch, M.L.Ruiz del Castillo, S. Sanchez-Cortés. "Encapsulation and isomerisation of curcumin with cyclodextrins characterized by electronic and vibrational spectroscopy". Vibrational Spectroscopy, 62, 292-298 (2012). doi:10.106/j.vib.spec.2012.06.008.

- R. Sardella, F. Ianni, B. Natalini, G.P. Blanch, M.L.Ruiz del Castillo. "Rapid detection of D-amino acids in cheese with a chiral ligand-exchange chromatography system". Current Analytical Chemistry, 8, 319-327 (2012). doi: 10.2174/157341112800392562

- V. Pérez-Fernández, E. Domínguez Vega, A.L. Crego, M.A. García, M.L Marina. "Recent advances in the analysis of antibiotics by Capillary Electrophoresis and Capillary Electrochromatography". Electrophoresis, 33, 127-146 (2012).

- L. Sánchez-Hernández, M. Castro-Puyana, M.L Marina, A.L. Crego. "Recent approaches in sensitive enantioseparations by Capillary Electrophoresis". Electrophoresis, 33, 228-242 (2012).

- L. Sánchez-Hernández, N. Nozal, M.L Marina, A.L. Crego. "Determination of non-protein amino acids and betaines in vegetable oils by flow-injection triple-quadrupole tandem mass spectrometry: a screening method for the detection of adulterations of olive oils". J. Agric. & Food Chem. 60, 896-903 (2012).

- P. Puchalska, M.L Marina, M.C. García. "Development of a reversed-phase high-performance liquid chromatography analytical methodology for the determination of antihypertensive peptides in maize crops". J. Chromatogr. A, 1234, 64-71 (2012).

- V. Pérez-Fernández, E. Domínguez-Vega, B. Chankvetadze, A.L. Crego, M.C. García, M.L Marina. "Evaluation of new cellulose-based chiral stationary phases Sepapak-2 and Sepapak-4 for the enantiomeric separation of pesticides by nano-LC and CEC". J. Chromatogr. A, 1234, 22-31 (2012).

- C. Montealegre, B. Rasines, R. Gómez, F.J de la Mata, C. García-Ruiz, M.L Marina. "Characterization of carboxylate-terminated carbosilane dendrimers and their evaluation as nanoadditives in capillary electrophoresis for vegetable protein profiling. J. Chromatogr. A, 1234, 16-21 (2012).

- C. Montealegre, V. Verardo, A.M. Gómez-Aravacam C. García-Ruiz, M.L Marina, M.F. Caboni. "Molecular characterization of phospholipids by high-performance liquid chromatography combined with an evaporative light scattering detector, high-performance liquid chromatography with mass spectrometry, and gas chromatography combined with a flame ionization detector in different oat varieties". J. Agric. & Food Chem, 60, 10963-10969 (2012).

- C. Montealegre, M. C. García, C. Del Río, M. L. Marina, C. García-Ruiz. “Separation of olive proteins by Capillary Gel Electrophoresis" Talanta, 97, 450-424 (2012).

- M. J. Sánchez Martinez, M T: Perez Corona, C. Cámara and Y. Madrid. “Selenite Biotransformation during brewing. Evaluation by-MS.HPLC-ICP" Talanta, 88, 272-276 (2012).

- R. Gonzalo-Lumbreras, J. Guinea, J. Sanz-Landaluze, C. Cámara. “Miniaturized extraction methods for triclosan in aqueous and fish roe samples. Bioaccumulation studies in zebrafish larvae (Danio Rerio)" Anal. Bioanal. Chem., 403, 927-937 (2012).

- Susana Cuello, Sonia Ramos, Yolanda Madrid, Jose L. Luque-Garcia, Carmen Cámara. “Differential Protein Expression of Hepatic Cells Associated to MeHg Exposure:Deepening Into the Molecular Mechanisms of Toxicity" Anal. Bioanal. Chem., 404, 315-324 (2012). DOI 10.1007/s00216-012-6042-3

- Susana Cuello, Pilar Ximenez-Embun, Isabel Ruppen, Helia B. Schonthaler, Keith Ashman, Yolanda Madrid, Jose L. Luque-Garcia and Carmen Camara. “Analysis of protein expression in developmental toxicity induced by MeHg in zebrafish". Analyst, 137, 5302 (2012).

- S. El-Amrani, M. Pena-Abaurrea, J. Sanz-Landaluzea, , L. Ramosb, J. Guineac, C. Cámara. “Bioconcentration of pesticides in Zebrafish eleutheroembryos (Danio rerio)". STOTEN, 425, 184-190 (2012).

- A. Salgado, A. Lopez,  A. M.  Matía, J. Sotelo, S. Zarco, R. Muñoz, C. Cámara and M. A. Rodriguez. “Response to arsenate treatment in Schizosaccharomyces pombe and the role of its arsenate reductase activity". PLOS-ONE, 7(8):e43208 doi:10.1371/Journal pone 0043208. 7(8):e43208(2012).

- M.A. García-Mayor; A. Gallego-Picó; R.M. Garcinuño-Martínez; P. Fernández-Hernando; J.S. Durand Alegría. “Matrix solid-phase dispersion method for the determination of macrolide antibiotics in sheep's milk". Food chemistry, vol 134, 553-558, (2012). Issn 0308-8146

- J. Gañan; A. Gallego-Picó; R.M. Garcinuño-Martínez; P. Fernández-Hernando; S. Morante; I. Sierra; J.S. Durand Alegría. “Development of a molecularly imprinted polymer matrix solid phase dispersion method for selective determination of b-estradiol as anabolic grown promoter in goat milk". Analytical and bioanalytical chemistry, vol 403, 3025-3029, (2012). Issn 1618-2642

- C. De Alda Garcilope; A. Gallego-Picó; J.C. Bravo Yague; R.M. Garcinuño Martínez; P. Fernández-Hernando. “Characterization of spanish honeys with protected designation of origin miel de granada according to their mineral content". Food chemistry, vol 135, 1785-1788, (2012). issn 0308-8146

- L. Enriquez-Gabeiras; A. Gallego-Picó; R.M. Garcinuño-Martínez; P. Fernández-Hernando; J.S. Durand Alegría. “Interference-free determination of illegal dyes in sauces and condiment by matrix solid phase dispersion (mspd) and liquid chromatography (HPLC_DAD)". Food chemistry, vol 135, 193-198, (2012). Issn 0308-8146

- Granado-Serrano, A.B., Martin, M.A., Bravo, L., Goya, L. and Ramos, S. Quercetin modulates Nrf2 and glutathione-related defences via p38 in HepG2 cells. Chem. Bio. Int. 195, 154-164 (2012) (DOI 10.1016/j.cbi.2011.12.005).

- Granado-Serrano, A.B., Martin, M.A., Bravo, L., Goya, L. and Ramos, S. Quercetin attenuates NF-kappa B pathway against TNFa-induced inflammation in hepatic cells. Nutr. Cancer 64, 588-598 (2012) (DOI:10.1080/01635581.2012.661513).

- Martín, M.A., Ramos, S., Rodríguez-Ramiro, I., Mateos, R. and Bravo, L. and Goya, L. Signal transduction pathways involved in the chemo-preventive effect of dietary antioxidants: study in HepG2 as a cell culture model. Current Nutr. Food Sci. 8, 112-121 (2012).

- Sarria, B., Martinez-Lopez, S., Fernandez-Espinosa, A., Gómez-Juaristi, M., Goya, L., Mateos, R. and Bravo, L. Effects of regularly consuming dietary fibre rich cocoa products on bowel habits in healthy subjects: a free-living, two-stage, randomized, crossover, single-blind intervention. Nutr. Metab. 9, 33 (2012) (DOI 10.1186/1743-7075-9-33).

- Queguineur, B., Goya, L., Ramos, S., Martin, M.A., Mateos, R., Guiry, M.D. and Bravo, L. Phloroglucinol: antioxidant properties and effects on cellular oxidative markers in human HepG2 cell line. Food Chem. Toxicol. 50, 2886-2893 (2012) (DOI 10.1016/j.fct.2012.05.026).

- Sarria, B., Mateos, R., Sierra-Cinos, J.L., Goya, L., García-Diz, L. and Bravo, L. Hypotensive, hypoglycaemic and antioxidant effects of consuming a cocoa product in moderately hypercholesterolemic humans. Food & Function 3, 867-874 (2012) (DOI 10.1039/c2fo10267f).

- Sarria, B., Mateos, R., Gallardo, E., Ramos, S., Martín, M.A., Bravo, L. and Goya, L. Nitroderivatives of olive oil phenols (hydroxytyrosol and hydroxytyrosyl acetate) and ethyl hydroxytyrosyl ether protect HepG2 cells against oxidative stress. Food Chem. Toxicol, 50, 3752-3758 (2012) (DOI 10.1016/j.fct.2012.07.030).

- Rodríguez-Ramiro, I., Ramos, S., Bravo, L., Goya, L. and Martín, M.A. Procyanidin B2 induces Nrf2 translocation and glutathione-S-transferase expression via ERKs and p38-MAPK pathways to protect human colonic cells against oxidative stress. Eur. J. Nutr. 51, 881-892 (2012) (DOI 10.1007/s00394-011-0269-1).

- Pereira-Caro, G., Sarria, B.,  Madrona, A., Espartero, J.L., Escuderos, M.E., Bravo, L. and Mateos, R. Digestive stability of hydroxytyrosol, hydroxytyrosyl acetate and alkyl hydroxytyrosyl ethers. Int. J. Food Sci. Nutr. 63, 703-707 (2012) (DOI: 10.3109/09637486.2011.652943).

- Tan, S-A., Ramos, S., Martin, M.A., Mateos, R., Harvey, M., Ramanathan, S., Najimudin, N., Alam, M., Bravo, L. and Goya, L. Protective effects of papaya extracts on tert-butyl hydroperoxyde mediated oxidative injury to human liver cells (an in vitro study). Free Rad. Antiox. 2, 10-19 (2012) (DOI 10.5530/ax.2012.2.10).

- León-González, A., Mateos, R., Ramos, S., Martín, M.A., Sarriá, B., Martín-Cordero, C., López-Lázaro, M., Bravo, L. and Goya, L. Characterization of phenolic compounds in extracts of Corema album berries and their chemo-protective activity in human HepG2 cells. Food Res. Int. 49, 728-738 (2012) (DOI 10.1016/j.foodres.2012.09.016).

- O. Hernández-Hernández, I. Calvillo, R. Lebrón-Aguilar, F.J. Moreno and M.L. Sanz. Hydrophilic interaction liquid chromatography coupled to mass spectrometry for the characterization of prebiotic galactooligosaccharides. J. Chromatogr. 1220 (2012) 57-67

- M. Sánchez-Martínez, E. Garvão P. da Silva, T. Pérez-Corona, C. Cámara, S. L.C. Ferreira, Y. Madrid. Talanta, 88 (2012) 272.

- E. Peñas, C. Martinez-Villaluenga, J. Frias, M.J. Sánchez-Martínez, M.T. Pérez-Corona, Y. Madrid, C. Camara, C. Vidal-Valverde. Food Chem.,132 (2012) 907.

- R. Gonzalo-Lumbreras, J Sanz Landaluze, J Guinea, C Cámara. Anal. Bional. Chem., 403 (2012) 927-937.



Mario A. Fernández, Belén Gómara and M.J González. "Occurrence of phthalates and their metabolites in the environment and human health implications". The Handbook of Environmental Chemistry. Editor: Damiá Barceló. Editorial: Springer. Berlín, Heidelberg (Alemania).(2012)

A. Escarpa, M.A. López and L. Ramos. "Capítulo 17. Miniaturization". Handbook of Green Analytical Chemistry”. Edit.: M. de la Guardia and S. Garrigues. Wiley, Oxford (UK).ISBN: 978-0-470-97201-4. (2012)

L. Ramos. "Capítulo 1. “Basics and advances in sampling and sample preparation”. Chemical analysis of food: techniques and applications”. Edit.: Y. Picó. Elsevier , The Netherlands. ISBN: 978-0-12-384862-8 (2012). DOI: 10.1016/B978-0-12-384862-8.00001-7.

Arribas-Lorenzo, G.; Morales, F.J. "Chapter 5. Advances in Molecular Toxicology”. Capítulo Libro Recent Insights in Acrylamide as Carcinogen in Foodstuffs. Elsevier. James C. Fishbein Eds. (2012) 163-193 978-0-444-59389-4 http://dx.doi.org/10.1016/B978-0-444-59389-4.00005-7

C. Esteve, M. L. Marina, M. C. García. "HPLC of food proteins”. Food Analysis by HPLC. 3th edition. Chapter 4. ISBN: 978-1-43983-0840 (2012).



  1. Martín, M.A., Ramos, S., Granado-Serrano, A.B., Rodríguez-Ramiro, I., Mateos, R., Bravo, L. Goya, L. Molecular Mechanisms Involved in Hydroxytyrosol protection against oxidative stress in HepG2 cells. In: Olive Oil and Health. ISBN: 978-1-61728-653-7. James D. Corrigan Ed. (In press)

  2. Mateos, R., Pereira-Caro, G., Goya, L., Bravo, L. Bioavailability and Metabolism of Virgin Olive Oil Phenolic Compounds. In: Olive Oil and Health. ISBN: 978-1-61728-653-7. James D. Corrigan Ed. (In press).